Helping liver cancer researchers to better help liver cancer patients.
We aim at obtaining liver cancer organoids directly from patient’s tumour tissue. This will facilitate assaying personalized anti-cancer therapeutic strategies and studying human liver cancer biology. It will also result in the replacement and reduction of animal use in liver cancer (specially PDXs for large drug testing) and, consequently, it will improve animal welfare (refinement), as less animals suffering from liver failure and/or liver cancer would be used.
The outcomes of this research will have a huge impact on liver cancer patients, liver cancer researchers and also the 3Rs, as it will prompt liver cancer investigators to replace the actual animal models (mainly rodents and dog) for human in vitro models. Meritxell Huch
See the steps to accomplish our goals.
Aim 1: Characterize
in depth 3D-Organoid Cancer Models
Aim 2: Validate
in vivo the Tumorogenicity of the Organoid Models obtained in Aim 1
Aim 3: Determine
whether the models obtained are applicable for drug-screening